The brain age gap estimation (BrainAGE) methiod

"The “brain age gap estimation (BrainAGE)” method, which utilizes structural MRI data to directly quantify acceleration or deceleration of individual brain aging, was the first brain aging estimation approach that

  1. established reference curves for healthy brain maturation during childhood into young adulthood and for healthy brain aging during adulthood into senescence,

  2. examined deviations of individual brain aging from the established reference curve of healthy brain aging in neurodegenerative diseases,

  3. analyzed longitudinal changes of individual brain aging in several samples,

  4. used deviations of individual brain age predictions from the established reference curve of healthy brain aging to predict worsening of cognitive functions and conversion to Alzheimer’s disease (AD),

  5. studied the effects of a number of several health- and lifestyle-related factors on individual brain aging,

  6. monitored the effects of protective interventions on individual brain aging, and

  7. was adapted to be also applied in experimental studies with rodents and non-human primates.

BrainAGE […] may improve the assessment of individual risks for neurological, neuropsychiatric and neurodegenerative diseases as well as aid in developing personalized neuroprotective treatments and interventions."