Ideas and protocol for economical longevity

Lifestyle, biomarker and supplement suggestions for near-term aging interventions at a reasonable cost… which should be less than $2,000/yr. Protocol is for middle-aged male but can provide insight to others. Feedback welcome!

Diet

  • Diet is the most critical ingredient for good health
  • Maintaining low and even blood sugar is essential
  • Zero-carb/carnivore or low-carb/paleo is suggested
  • Water is the preferred (low-cost) beverage of choice

Fasting

  • Intermittent fasting is a powerful autophagy inducer
  • Skip breakfast and lunch as often as possible
  • Every month, fast for 2 to 3 days

Hormesis

  • Short-term, high-intensity stress for stem-cell activation
  • High-intensity workouts, hot/cold showers, sun or infrared sauna

Sleep

  • Optimal sleep is essential for health and recovery

Health Tracking & Biomarkers

  • Sleep - measure daily
  • Weight - measure daily
  • Blood pressure - measure weekly
  • Glucose - measure weekly before and after meals ($200/yr)
  • Comprehensive blood panel - measure yearly ($200/yr)
  • Epigenetic biomarker - measure yearly (optional, $300/yr)

Supplements ($1,300/yr)

The following is a brief listing of supplements that may help with energy, antiviral and longevity health. Please do your own research before taking.

  • NR (Nicotinamide Riboside)
  • Niacin (flush inducing)
  • PQQ
  • Inositol
  • Phosphatidylcholine
  • Lithium Aspartate
  • Magnesium
  • Vitamin D3
  • Fisetin (liposomal)
  • Lutein
  • NAC (N-Acetyl Cysteine)
  • Alpha Lipoic Acid
  • Pterostilbene
  • Vitamin K-2
  • Berberine
  • Oil of Oregano
  • Methylene Blue
  • Creatine
  • Amino Acids

Advanced and/or more expensive:

  • DHEA
  • Pregnenolone
  • Metformin
  • Dasatinib/Quercetin (2/yr = synolitic)
  • Exosomes
  • Peptides
  • PRP

I will start criticizing your suggestion, if you don’t mind. Generally speaking, the suggested diet and supplements will kill you faster than time itself.

Don’t mind at all… plan to respond soon.

  • NR (Nicotinamide Riboside) - no clinically beneficial effects: “Oral NR does not alter systemic cardiometabolic parameters.”

  • Niacin (flush inducing) - increases blood glucose levels, can cause liver damage, hypotension and might activate a peptic ulcer

  • PQQ - useless unless a subject on statins

  • Inositol - shows low-quality clinical benefits

  • Phosphatidylcholine - some subjects might develop atherosclerosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086762/

  • Lithium Aspartate - yes, yet dosage unknown

  • Magnesium - yes

  • Vitamin D3 - as well as other vitamins, such as B12, the deficiency should be managed. Additional vitamin D3 supplementation reduces all-cause mortality by just 6%, which is an equivalent of less than 7 additional months of life and not associated with lower rates of invasive cancer or cardiovascular events. Moreover, there is a notion that the serum 25(OH)D3 in is actually a surrogate marker of the level of insolation, which is accountable for the benefits commonly associated with vitamin D.

  • Fisetin (liposomal) - requires more studies about regime and dosage

  • Lutein - yes

  • NAC (N-Acetyl Cysteine) - antioxidant, might speed up the growth of some cancers

  • Alpha Lipoic Acid - antioxidant, reduces lifespan

  • Pterostilbene - requires more studies about regime and dosage

  • Vitamin K-2 - yes, yet requires more studies about regime and dosage, for example “MK-7 supplementation tended to increase active calcification” https://academic.oup.com/ajcn/advance-article/doi/10.1093/ajcn/nqz147/5544545

  • Berberine - requires more studies about regime and dosage

  • Oil of Oregano - exhibits low-quality clinical benefits

  • Methylene Blue - dangerous https://www.ncbi.nlm.nih.gov/pubmed/22197611

  • Creatine - after a certain age

  • Amino Acids - after a certain age

Some bacteria are being killed. Perhaps they are the bad kind and/or there is a shift in the quality. Either way, why are there so many positive health effects from the diet?

Quoting from the above article, “Its efficacy in reducing seizures has been confirmed, but the mechanisms remain elusive. The diet has also shown positive effects in a wide range of other diseases, including Alzheimer’s, depression, autism, cancer, and type 2 diabetes.”

This articles focused on type 1 and type 2 diabetics… rather than healthy cohorts. Wouldn’t doubt that increasing ketone bodies w/in non-adapted or unhealthy individuals would cause problems. For individuals who’ve had weeks or months of ketogentic adaptation, I suspect things are much different.

Not sure if this kind of platelet function change leads to increased stroke risk. The study (only six patients) measured excessive bruising/bleeding right? Perhaps the injury was from a greater feeling of energy from the diet? :wink: Otherwise, this just seems a little to esoteric to make a call about such an important claim.

Only 6 patients… with existing disease and disabilities. Not the most robust of studies. Also, what the hell is Ketonformula? In the article they say “Ketonformula is a foumula(sp?) for a ketogenic diet developed by Meiji Co Ltd in Japan. No reports are available on the trace mineral deficiencies associated with a use of Ketonformula.” Sounds very much like a bias in the study perhaps?

Association study… could be various other factors leading to kidney stones… family history, dehydration or excess Vit D. These children are not healthy to begin with. It’s not surprising that a few may have other health problems. Another could be adherence to the diet in such a young population. Another could be adaptation phase response to the diet where uric acid levels go up early on… sure, but the kidney adapts (in healthy individuals) to maintaining normal uric acid excretion long-term.

Many studies show that keto is helpful in fighting cancer:

“Tumor cells have an increased reliance on glucose, suggesting that treatments affecting cellular metabolism may be an effective method to improve current therapies. Indeed, metabolism has been a focus of cancer research in the last few years, as many pathways long associated with tumor growth have been found to intersect metabolic pathways in the cell. The ketogenic diet (high fat, low carbohydrate and protein), caloric restriction, and fasting all cause a metabolic change, specifically, a reduction in blood glucose and an increase in blood ketones. We, and others, have demonstrated that these metabolic changes improve survival in animal models of malignant gliomas and can potentiate the anti-tumor effect of chemotherapies and radiation treatment.”

Concerning the stack… I plan to detail a bit more of the thinking behind the supplement suggestions and how best to take them. Importantly, many are only taken w/in a short window for specific purposes.

Overall, those contraindications would not allow me to recommend the long-term keto for promoting longevity. It requires more studies and needs to be personalized.

Agree, everyone is different, so tailoring diets is important. Just personally, keto has been a rather remarkable life enhancer with numerous benefits. What I’ve learned is that I need to go fully into zero/low-carb, high-fat, moderate protein for weeks/months to gain most benefits. More studies are finding benefits. Most recently this one from MIT hints at stem cell enhancements:

“MIT biologists have discovered an unexpected effect of a ketogenic, or fat-rich, diet: They showed that high levels of ketone bodies, molecules produced by the breakdown of fat, help the intestine to maintain a large pool of adult stem cells, which are crucial for keeping the intestinal lining healthy.”

https://www.eurekalert.org/pub_releases/2019-08/miot-slc_1082019.php