How to reduce scar thickness?

  1. Moore, A. L. et al. Doxycycline Reduces Scar Thickness and Improves Collagen Architecture. Ann Surg Publish Ahead of Print, (2018).

"A one-time dose of 3.90 mM doxycycline (2 mg/mL) within 12 hours of injury was found to significantly reduce scar thickness by 24.8% (P < 0.0001) without compromising tensile strength.
The same effect could not be achieved by oral dosing.
In doxycycline-treated scar matrices, collagen I content was significantly reduced (P = 0.0317) and fibers were favorably arranged with significantly increased fiber randomness (P = 0.0115).

Common culprits of altered wound healing mechanics, including angiogenesis and inflammation, were not impacted by doxycycline treatment.

However, engrailed-1 profibrotic fibroblasts, responsible for scar extracellular matrix deposition, were significantly reduced with doxycycline treatment (P = 0.0005)."

  1. Derry, D. M. Successful human scar regeneration by topical iodine. Medical Hypotheses 72, 553–561 (2009).

“The 50 year old scar regenerated completely 2 years ago. Small experiments on regeneration are possible because it is a slow process and more importantly can be stopped and started at will. These results support the proposed hypothesis topical iodine initiates, controls, and completes human scar regeneration.”

  1. Postburn Hypertrophic Scar Response to Potassium Iodide