- Moore, A. L. et al. Doxycycline Reduces Scar Thickness and Improves Collagen Architecture. Ann Surg Publish Ahead of Print, (2018).
"A one-time dose of 3.90 mM doxycycline (2 mg/mL) within 12 hours of injury was found to significantly reduce scar thickness by 24.8% (P < 0.0001) without compromising tensile strength.
The same effect could not be achieved by oral dosing.
In doxycycline-treated scar matrices, collagen I content was significantly reduced (P = 0.0317) and fibers were favorably arranged with significantly increased fiber randomness (P = 0.0115).
Common culprits of altered wound healing mechanics, including angiogenesis and inflammation, were not impacted by doxycycline treatment.
However, engrailed-1 profibrotic fibroblasts, responsible for scar extracellular matrix deposition, were significantly reduced with doxycycline treatment (P = 0.0005)."
- Derry, D. M. Successful human scar regeneration by topical iodine. Medical Hypotheses 72, 553–561 (2009).
“The 50 year old scar regenerated completely 2 years ago. Small experiments on regeneration are possible because it is a slow process and more importantly can be stopped and started at will. These results support the proposed hypothesis topical iodine initiates, controls, and completes human scar regeneration.”