All of Us Research Program

"By enrolling one million or more volunteers, the All of Us Research Program will have the scale and scope to enable research for a wide range of diseases, both common and rare, as well as increase our understanding of healthy states.
Additionally, a research program of this size will have the statistical power to detect associations between environmental and/or biological exposures and a wide variety of health outcomes. Among the scientific opportunities presented by All of Us is the ability to:

  • develop ways to measure risk for a range of diseases based on environmental exposures, genetic factors and interactions between the two;
  • identify the causes of individual differences in response to commonly used drugs (commonly referred to as pharmacogenomics);
  • discover biological markers that signal increased or decreased risk of developing common diseases;
  • use mobile health (mHealth) technologies to correlate activity, physiological measures and environmental exposures with health outcomes;
  • develop new disease classifications and relationships;
  • empower study participants with data and information to improve their own health; and
  • create a platform to enable trials of targeted therapies."

All participants who consent to be a part of the program must complete a core set of surveys on the secure Participant Portal (learn more about how participants join here). Some participants will complete more health surveys during their participation in the program.
Core surveys include extensive questions on health and lifestyle factors. Additional surveys will be incorporated over time by the program. You can view survey questions and learn more about where they came from using our Survey Explorer.
Some participants will agree to share information from their electronic health records (EHR). The program removes personal identifiers from EHR data before adding this information to the Research Hub
We use the Observational Medical Outcomes Partnership (OMOP) to standardize all EHR data. Learn more about OMOP on our Data Methods page.
Some participants will provide physical measurements at one of our All of Us Research Program Partner locations. Measurements collected include: height, weight, BMI, waist circumference, hip circumference, pregnancy-status, blood pressure, heart rate, and wheelchair use.
Further explore our collection of physical measurements in the Data Browser.
Some participants contribute urine and saliva samples. These samples are stored in our biobank at the Mayo Clinic for later analyses, including genomic sequencing. In the future, genetic data will become available on the Research Hub for registered and approved researchers.
The program also has begun collecting information from wearable health tracking technology. Wearables track biometric data like heart rate and blood pressure.