"Here we propose an averaged and deterministic model, based on cell population dynamics, replicative senescence and functionality loss.
It describes the age-related change of performance in 17 time-series phenotypic traits, including human physical and cognitive skills, mouse lemur strength, greyhound and thoroughbred speed, and mouse activity.
We demonstrate that the estimated age of peak performance occurs in the early part of life (20.5% ± 6.6% of the estimated lifespan) thus emphasizing the asymmetrical nature of the relationship.
This model is an initial attempt to relate performance dynamics to cellular dynamics and will lead to more sophisticated models in the future."
Berthelot, G. et al. An integrative modeling approach to the age-performance relationship in mammals at the cellular scale. Scientific Reports 9, (2019).